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Trazodone 50 mg (Desyrel)

Trazodone 50 mg This medicine is a modified cyclic antidepressant used to treat depression. Buy Trazodone (Desyrel ) 50 mg 90 tablets (Generic) $23.00
The use of Trazodone:
Trazodone Depressive states of various etiologies (endogenous, psychotic, neurotic, somatogenic, etc.) with severe anxiety, tension, pain from neuralgia, agoraphobia, alcohol abstinence, drug dependence to benzodiazepines, decreased libido, impotence.

Contraindications Trazodone:
Hypersensitivity, myocardial infarction (early recovery period), ventricular arrhythmia, extrasystoles, tachycardia, hepatic and / or renal failure, pregnancy, lactation, age 6 years.

Restrictions apply to Trazodone:
Hypertension (may require dose adjustment of antihypertensive drugs), priapism in history, the age of 18.

The use of Trazodone in pregnancy and lactation:
Contraindicated during pregnancy. At the time of treatment should abandon breastfeeding.

Side effects Trazodone:
Since the nervous system and sensory organs: fatigue, weakness, headache, dizziness, insomnia, drowsiness, agitation, psychosis, hypomania, hallucinations, tremors, muscle twitching, large seizures (grand mal), aphasia, ataxia, akathisia , dyskinesia, paresthesias, confusion, syncope, blurred vision, double vision.

With the cardiovascular system and blood (hematopoiesis, hemostasis): hypotension, including orthostatic; atrial fibrillation, arrhythmia (including tachy and bradycardia, ventricular ectopic beats), congestive heart failure, leukocytosis or leukopenia, neutropenia (usually minor), hemolytic anemia, methemoglobinemia.

From the digestive tract: increased appetite, dryness and an unpleasant taste in the mouth, hypersalivation, dental caries, the disease around dental tissues, oral candidiasis, nausea, vomiting, flatulence, diarrhea, constipation, cholestasis, increased levels of bilirubin and amylase in the blood plasma, jaundice .

With the genitourinary system: urinary retention, frequent urination, hematuria, early menstruation, hirsutism, increased libido, priapism, impotence, retrograde ejaculation.

Allergic reactions: skin rash, urticaria.

Other: myalgia, chest pain, alopecia, psoriasis, edema.

Interaction Trazodone:
Unlike typical anti-depressant does not decrease the effects of reserpine deprimiruyuschie weakens the central action of amphetamine and peripheral – norepinephrine. Potentiates the effect of oppressive central nervous system (including barbiturates, tricyclic antidepressants, antihistamines, clonidine and alcohol), anticholinergic drugs and muscle relaxants. When concomitantly with antihypertensive drugs increases the risk of orthostatic hypotension. Weakens the effect of psychostimulants. Increases the plasma concentration of digoxin and phenytoin. Should not be used concurrently with MAO inhibitors.

An overdose of Trazodone:
Symptoms: Nausea, vomiting, drowsiness, dizziness, lowering of blood pressure, loss of coordination, priapism, epileptiform seizures, ECG changes, respiratory arrest, weighting of adverse reactions.
Treatment: gastric lavage, forced diuresis, intake of activated carbon, maintaining the vital functions, symptomatic therapy. No specific antidote.

Administration and Dosage Trazodone:
V / m / in. Inside, during or immediately after a meal, 2-3 hours (2 / 3 of daily dose – before bedtime).
Adults: 150 mg / day, if necessary, increase the dose to 50 mg / day every 3-4 days to achieve a therapeutic effect. The maximum daily dose on an outpatient basis – 450 mg, stationary – 600 mg. Maintenance dose in mild forms of depression – 150 mg / day for moderate and heavy – 300 mg / day. For elderly and debilitated patients with an initial dose of 75 mg / day, if necessary, may be increased to 300 mg / day. Children 6-18 years: 1,5-2 mg / kg / day, if necessary, increase the dose to 6 mg / kg / day.

Violations of the libido: 50 mg / day. Impotence: 200 mg / day monotherapy, 50 mg / d in the complex therapy. Benzodiazepine dependence: a stepwise reducing the dose of benzodiazepines at 1 / 4 or 1 / 2 tablets, while adding 50 mg of trazodone, for 3 weeks, then continue decreasing the dose of benzodiazepines up to cancel, then reduce the dose of trazodone 50 mg / day every 3 weeks. Premedication: IM, IV 50 mg.

Precautions Trazodone:
During the treatment should be regularly CBC (to detect and leuco-neutropenia), ECG monitoring is desirable in patients with cardiovascular diseases. Requires careful observation of patients with suicidal tendencies, especially in the first week of treatment. Treatment immediately cease the development of priapism, severe leukopenia and neutrons in other cases, the abolition of the drug should be gradual. During treatment you should avoid drinking alcohol. Be wary of during the drivers of vehicles and people whose activities are associated with increased concentration.
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